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., 1997). It absolutely was verified that this impact was mediated through the CB1 receptor and happened at a dose which was not affiliated with clear Negative effects. This analyze also shown a rise in thermal hyperalgesia and mechanical allodynia by administration of SR141716a on your own, top the authors to infer the existence of the endogenous tone of cannabinoid analgesia in neuropathy. However, the evidence for these tone throughout inflammation is controversial (Beaulieu et al
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